Published or in press articles:
Work Package 1:
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Spoorendonk KM, Peterson-Maduro J, Renn J, Trowe T, Kranenbarg S, Winkler C and Schulte- Merker S (2008) Retinoic acid and Cyp26b1 are critical regulations of osteogenesis in the axial skeleton. Development 135: 3765-3774.
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Hammond CL, Schulte-Merker S (2009) Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signaling. Development 136: 3991-4000.
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Spoorendonk KM, Hammond CL, Huitema LFA, Vanoevelen J, and Schulte-Merker S (2010) Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Journal of Applied Ichtyologie 26(2):219-224.
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Work
Package 2:
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Mione M, Meijer AH, Snaar-Jagalska BE, Spaink HP, Trede NS (2009) Disease modeling in zebrafish: cancer and immune responses-a report on a workshop held in Spoleto, Italy, July 20-22, 2009. Zebrafish 6: 445-51.
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van der Sar AM, Spaink HP, Zakrzewska A, Bitter W, Meijer AH (2009) Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. Mol Immunol. 46: 2317-32.
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Sieger D, Stein C, Neifer D, van der Sar AM, Leptin M (2009) The role of gamma interferon in innate immunity in the zebrafish embryo. Dis Model Mech. 2: 571-81.
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Llamas MA, van der Sar A, Chu BC, Sparrius M, Vogel HJ, Bitter W (2009) A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa. Plos Pathogen 5(9): e10000572.
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Meijer AH, Spaink HP. Host-pathogen interactions made transparent with the zebrafish model. Current Drug Targets (invited review, in press).
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Carvalho R, de Sonneville J, Stockhammer OW, Savage ND, Veneman W, Dirks RP, Meijer AH, Spaink HP. A high-throughput screen for tuberculosis progression. PlosONE, in press.
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Zakrzewska A, Cui C, Stockhammer OW, Benard EL, Spaink HP, Meijer AH. (2010) Macrophage-specific gene functions in Spi1-directed innate immunity. Blood 116:e1-11.
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Peng K, Cui C, Tomatsu I, Porta F, Meijer AH, Spaink HP, Kros A (2010) Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos. Soft matter 6: 3778-3783.
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Stoop EJM, Schipper T, Rosendahl Huber SK, Nezhinsky AE, Verbeek FJ, Gurcha SS, Besra GS, Vandenbroucke-Grauls CMJE, Bitter W, van der Sar AM. Zebrafish embryo screen for mycobacterial genes involved in granuloma formation reveals a novel ESX-1 component. Dis. Mech. Models. in press.
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Work Package 3:
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Schaaf MJ, Champagne D, van Laanen IH, van Wijk DC, Meijer AH, Meijer OC, Spaink HP, Richardson MK (2008) Discovery of a functional glucocorticoid receptor ß-isoform in zebrafish. Endocrinology 149(4):1591-9.
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Kruyt MC, Dhert WJ, Oner FC, van Blitterswijk CA, Verbout AJ and de Bruijn J (2007) Analysis of ectopic and orthotopic bone formation in cell-based tissue-engineered constructs in goats. Biomaterials 28: 1798-1805.
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Meijer GJ, de Bruijn JD, Koole R and van Blitterswijk CA (2007) Cell-based bone tissue engineering. PLoS Med Feb 20;4(2): e9.
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Eniwumide JO, Yuan H, Cartmell SH, Meijer GJ and de Bruijn JD (2007) Ectopic bone formation in bone marrow stem cell seeded calcium phosphate scaffolds as compared to autograft and (cell-seeded) allograft. Eur Cells and Mater, 14: 30-39.
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Vonk FJ, Admiraal JF, Jackson K, Reshef R, de Bakker MA, Vanderschoot K, van den Berge I, van Atten M, Burgerhout E, Beck A, Mirtschin PJ, Kochva E, Witte F, Fry BG, Woods AE, Richardson MK (2008) Evolutionary origin and development of snake fangs. Nature 454:630-633.
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Schaaf MJ, Koopmans WJ, Meckel T, van Noort J, Snaar-Jagalska BE, Schmidt TS, Spaink HP (2009) Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate. Biophys J. 97(4):1206-14.
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Van der Vaart M, Schaaf MJ (2009) Naturally occurring C-terminal splice variants of nuclear receptors. Nucl. Recept. Signal. 7:e007.
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Brittijn SA, Duivesteijn SJ, Belmamoune M, Bertens LF, Bitter W, de Bruijn JD, Champagne DL, Cuppen E, Flik G, Vandenbroucke-Grauls CM, Janssen RA, de Jong IM, de Kloet ER, Kros A, Meijer AH, Metz JR, van der Sar AM, Schaaf MJ, Schulte-Merker S, Spaink HP, Tak PP, Verbeek FJ, Vervoordeldonk MJ, Vonk FJ, Witte F, Yuan H, Richardson MK (2009) Zebrafish development and regeneration: new tools for biomedical research. Int J Dev Biol. 53(5-6):835-50.
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Schaaf MJ, Chatzopoulou A, Spaink HP (2009) The zebrafish as a model system for glucocorticoid receptor research. Comp Biochem Physiol A Mol Integr Physiol. 2009 153(1):75-82.
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Sarabdjitsingh RA, Meijer OC, Schaaf MJ, de Kloet ER (2009) Subregion-specific differences in translocation patterns of mineralocorticoid and glucocorticoid receptors in rat hippocampus. Brain Res. 1249:43-53.
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Versluis F, Tomatsu I, Kehr S, Fregonese C, Stuart MCA, Ravoo BJ, Koning RI, Kros A (2009) Shape and release control of a vesicle through the pH sensitive secondary structure transition of a non-covalently bound oligopeptide. J. Am. Chem. Soc. 131:13186–13187.
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Oitzl MS, Champagne DL, van der Veen R, de Kloet ER (2009) Brain development under stress: hypotheses of glucocorticoid actions revisited. Neurosci. & Biobehav. Rev (Epub, ahead of print).
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Smit-Rigter LA, Champagne DL, van Hooft JA (2009) Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring. PLoS ONE 4:e5167.
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Vreugdenhil E, Verissimo C, Mariman R, Kamphuis JT, Barbosa JS, Champagne DL, Meijer OC, de Kloet ER, Fitzsimons C. (2009) Discovery of a Novel Role for MicroRNAs miR-18 and miR-124 in Reducing Glucocorticoid Receptor Activity and GR Protein Levels: Implications for the Regulation of Glucocorticoid Responsiveness. Endocrinology 150:2220-2228.
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Champagne DL, de Kloet ER, Joels M (2009) Fundamental aspects of the impact of glucocorticoids on the (immature) brain. Seminars in Fetal and Neonatal Medicine 14(3):136-42.
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de Jong IM, Colbert MW, Witte F, Richardson MK (2009) Polymorphism in developmental timing: intraspecific heterochrony in a Lake Victoria cichlid. Evol Dev. 11(6):625-35.
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de Jong IM, Witte F, Richardson MK (2009) Developmental stages until hatching of the Lake Victoria cichlid Haplochromis piceatus (Teleostei: Cichlidae).J Morphol. 270(5):519-35.
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Blackburn DG, Richardson MK (2009) Preface to the symposium "Trends in the Evolution of Amniote Embryos". J Exp Zool B Mol Dev Evol. 312(6):525.
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Chuong CM, Richardson MK (2009) Pattern formation today. Int J Dev Biol. 53(5-6):653-8.
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Chuong CM, Richardson MK (2009) Preface to pattern formation special issue. Int J Dev Biol. 53(5-6):651.
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Woltering JM, Vonk FJ, Müller H, Bardine N, Tuduce IL, de Bakker MA, Knöchel W, Sirbu IO, Durston AJ, Richardson MK (2009) Axial patterning in snakes and caecilians: evidence for an alternative interpretation of the Hox code. Dev Biol. 332(1):82-9.
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Richardson MK, Gobes SM, van Leeuwen AC, Polman JA, Pieau C, Sánchez-Villagra MR (2009) Heterochrony in limb evolution: developmental mechanisms and natural selection. J Exp Zool B Mol Dev Evol. 312(6):639-64.
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De Vrieze E, Metz JR, Von den Hoff JW, Flik G (2010) ALP, TRAcP and cathepsin K in elasmoid scales: a role in mineral metabolism? Journal of Applied Ichthyology 26:210-213.
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De Vrieze E, Sharif F, Metz JR, Flik G, Richardson MK. Matrix metalloproteinases in osteoclasts of ontogenetic and regenerating zebrafish scales. Bone [Epub ahead of print]
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Peng K, Cui C, Tomatsu I, Meijer AH, Spaink HP, Kros A (2010) Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos. Soft Matter 6:3778–3783.
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Peng K, Tomatsu I, Kros A (2010) Light controlled protein release from a supramolecular hydrogel. Chem. Commun. 46:4094 – 4096.
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Peng K, Tomatsu I, Korobko AV, Kros A (2010) Rapid in Situ Forming Cross-linked Dextran/β-cyclodextrin Hydrogels for the Delivery of Hydrophobic Drugs. Soft Matter 6:85-87.
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Schoonheim PJ, Chatzopoulou A, Schaaf MJ (2010) The zebrafish as an in vivo model system for glucocorticoid resistance. Steroids. 75(12):918-25.
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Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AMC, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (2010) Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. PNAS 107:13614-19.
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Yuan H, De Bruijn J (2010) Heterotopic bone formation by nano-apatite containing poly(D,L-lactide) composites.EUROPEAN CELLS & MATERIALS19:252-261.
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Barbieri D, Renard AJS, de Bruijn JD, Yuan H (2010) Heterotopic bone formation by nano-apatite containing poly(D,LLactide) composites. European Cells & Materials 19:252-61.
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Claessens SE, Daskalakis NP, van der Veen R, Oitzl MS, de Kloet ER, Champagne DL (2010) Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences. Psychopharmacology (Berl) (epu ahead of print).
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Steenbergen PJ, Richardson MK, Champagne D.L. (2010) The use of the zebrafish model in stress research.Prog Neuropsychopharmacol Biol Psychiatry (epu ahead of print).
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Champagne DL, Hoefnagels C, de Kloet ER, Richardson MK (2010) Translating Rodent Behavioral Repertoire to Zebrafish (Danio rerio): Relevance for Stress Research. Behav Brain Res. 214:332-42.
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Qiu S, Champagne DL, Peters M, Weeber EJ, Levitt P, Pimenta AF (2010) Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity and spatial memory deficit.Biol Psychiatry 68(2):197-204.
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Ali S, Champagne DL, Alia A, Richardson MK. Largeāscale analysis of acute ethanol exposure in zebrafish development: a critical time window and resilience (in revision with PLoS ONE).
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Ali S, Champagne DL, van der Mil HA, Richardson MK. Critical assessment of the zebrafish embryo as a predictive model for the acute drug toxicity (In preparation for Toxicological Sciences).
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Richardson MK, Admiraal J, Wright GM (2010) Developmental anatomy of lampreys. Biol Rev Camb Philos Soc. 85(1):1-33.
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Siang AS, Doley R, Vonk FJ, RM Kini (2010) Transcriptomic Analysis of the Venom Gland of the Red-headed Krait (Bungarus flaviceps) Using Expressed Sequence Tags. BMC Molecular Biology 11, 24.
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Work Package 4:
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Hoekema A (2007) Galapagos and GSK: An innovative alliance in osteoarthritis. Global Outsourcing Review 9: 26-28. |
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Hoekema A (2007) Sharing risks and rewards: basis for a turnkey pharma-biotech alliance in osteoarthritis. Drug Discovery World 8: 53-58.
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Joubert O, Nehmé R, Fleury D, De Rivoyre M, Bidet M, Polidori A, Ruat M, Pucci B, Mollat P, Mus-Veteau I (2009) Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast. Biochim Biophys Acta. 1788(9):1813-21.
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Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC (2009) Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 9:26.
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Hourdé C, Jagerschmidt C, Clément-Lacroix P, Vignaud A, Ammann P, Butler-Browne GS, Ferry A (2009) Androgen replacement therapy improves function in male rat muscles independently of hypertrophy and activation of the Akt/mTOR pathway. Acta Physiol (Oxf). 195(4):471-82.
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Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann M, Deprez P, Clément-Lacroix P, Bettler B, Bräuner-Osborne J(2009) No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Mol. Endocrinol. 42(3):215-23
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Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delecourte A, Fischer DF, Pollet D, De Strooper B, and Merchiers P (2009) The orphan G protein coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science 323(5916):946-951.
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Kollias G, Papadaki P, Apparaille F, Vervoordeldonk MJ, Holmdahl R, Gay S. Eular study group on animal models-Guidance document. Submitted for publication.
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