Published or in press articles:
Work Package 1:
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Spoorendonk KM, Peterson-Maduro J, Renn J, Trowe T, Kranenbarg S, Winkler C and Schulte- Merker S (2008) Retinoic acid and Cyp26b1 are critical regulations of osteogenesis in the axial skeleton. Development 135: 3765-3774.
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Hammond CL, Schulte-Merker S (2009) Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signaling. Development 136: 3991-4000.
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Spoorendonk KM, Hammond CL, Huitema LFA, Vanoevelen J, and Schulte-Merker S (2010) Zebrafish as a unique model system in bone research: the power of genetics and in vivo imaging. Journal of Applied Ichtyologie 26(2):219-224.
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Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S and Weidinger G (2011) Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Developmental Cell 20, 713-724.
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Vanoevelen J, Janssens A, Huitema LFA, Hammonds CL, Metz JR, Flik G, Voets T and Schulte-Merker S (2011) Trpv5/6 is vital for epithelial calcium uptake and bone formation. FASEB Journal 25(9): 3197-207.
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Work
Package 2:
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Mione M, Meijer AH, Snaar-Jagalska BE, Spaink HP, Trede NS (2009 Disease modeling in zebrafish: cancer and immune responses - a report on a workshop held in Spoleto, Italy, Juli 20-22, 2009, Zebrafish 6: 445-51.
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van der Sar AM, Spaink HP, Zakrzewska A, Bitter W, Meijer AH (2009) Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the rol of innate and adaptive immune components. Mol Immunol. 46: 2317-32
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Sieger D, Stein C, Neifer D, van der Sar AM, Leptin M (2009) The rol of gamma interferon in innate immunity in the zebrafish embryo. Dis Model Mech. 2: 571-81.
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Llamas MA, van der Sar A, Chu BC, Sparrius M, Vogel HJ, Bitter W (2009) A Novel extracytoplasmic function (ECF) sigma factor regulates virulence in Pseudomonas aeruginosa. Plos Pathogen 5(9): e10000572.
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Zakrzewska A, Cui C, Stockhammer OW, Benard EL, Spaink HP, Meijer AH (2010) Macrophage-specific gene functions in Spi1-directed innate immunity. Blood 116:e1-11
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Peng K, Cui C, Tomatsu I, Porta F, Meijer AH, Spaink HP, Kros A (2010) Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos. Soft matter 6: 3778-3783.
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Carvalho R, de Sonneville J, Stockhammer OW, Savage ND, Veneman W, Dirks RP, Meijer AH, Spaink HP (2011) A high-throughput screen for tuberculosis progression. PlosONE 6(2):e16779.
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Cui C, Benard EL, Kanwal Z, Stockhammer OW, van der Vaart M, Zakrzewska A, Spaink HP, Meijer AH (2011) Infectious disease modeling and innate immune function in zebrafish embryos. Methods Cell Biol 105:273-308.
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Holt A, Mitra S, van der Sar AM, Alnabulsi A, Secombes CJ, Bird S (2011) Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23α ) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation. Mol Immunol. 48:981-91.
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Meijer AH, Spaink HP (2011) Host-pathogen interactions made transparent with the zebrafish model. Current Drug Targets 12(7):1000-1017.
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Peng K, Tomatsu I, van den Broek B, Cui C, Korobko AV, van Noort J, Meijer AH, Spaink HP, Kros A (2011) Dextran based photodegradable hydrogels formed via a Michael addition. Soft Matter 7:4881-4887.
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Stoop EMJ, Schipper T, Rosendahl Huber SK, Nezhinsky AE, Verbeek FJ, Gurcha SS, Besra GS, Vandenbroucke-Grauls CMJE, Bitter W, van der Sar AM (2011) Zebrafish embryo screen for mycobacterial genes involved in granuloma formation reveals a novel ESX-1 component. Dis. Mech. Models. 4(4): 526-536.
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Benard EL, van der Sar AM, Ellett F, Lieschke GJ, Spaink HP, Meijer AH. Infection of zebrafish embryos with intracellular bacterial pathogens. Journal of Visualized Experiments, in press
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Work Package 3:
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Schaaf MJ, Champagne D, van Laanen IH, van Wijk DC, Meijer AH, Meijer OC, Spaink HP, Richardson MK (2008) Discovery of a functional glucocorticoid receptor ß-isoform in zebrafish. Endocrinology 149(4):1591-9.
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Kruyt MC, Dhert WJ, Oner FC, van Blitterswijk CA, Verbout AJ and de Bruijn J (2007) Analysis of ectopic and orthotopic bone formation in cell-based tissue-engineered constructs in goats. Biomaterials 28: 1798-1805.
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Meijer GJ, de Bruijn JD, Koole R and van Blitterswijk CA (2007) Cell-based bone tissue engineering. PLoS Med Feb 20;4(2): e9.
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Eniwumide JO, Yuan H, Cartmell SH, Meijer GJ and de Bruijn JD (2007) Ectopic bone formation in bone marrow stem cell seeded calcium phosphate scaffolds as compared to autograft and (cell-seeded) allograft. Eur Cells and Mater, 14: 30-39.
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Vonk FJ, Admiraal JF, Jackson K, Reshef R, de Bakker MA, Vanderschoot K, van den Berge I, van Atten M, Burgerhout E, Beck A, Mirtschin PJ, Kochva E, Witte F, Fry BG, Woods AE, Richardson MK (2008) Evolutionary origin and development of snake fangs. Nature 454:630-633.
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Schaaf MJ, Koopmans WJ, Meckel T, van Noort J, Snaar-Jagalska BE, Schmidt TS, Spaink HP (2009) Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate. Biophys J. 97(4):1206-14.
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Van der Vaart M, Schaaf MJ (2009) Naturally occurring C-terminal splice variants of nuclear receptors. Nucl. Recept. Signal. 7:e007.
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Brittijn SA, Duivesteijn SJ, Belmamoune M, Bertens LF, Bitter W, de Bruijn JD, Champagne DL, Cuppen E, Flik G, Vandenbroucke-Grauls CM, Janssen RA, de Jong IM, de Kloet ER, Kros A, Meijer AH, Metz JR, van der Sar AM, Schaaf MJ, Schulte-Merker S, Spaink HP, Tak PP, Verbeek FJ, Vervoordeldonk MJ, Vonk FJ, Witte F, Yuan H, Richardson MK (2009) Zebrafish development and regeneration: new tools for biomedical research. Int J Dev Biol. 53(5-6):835-50.
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Schaaf MJ, Chatzopoulou A, Spaink HP (2009) The zebrafish as a model system for glucocorticoid receptor research. Comp Biochem Physiol A Mol Integr Physiol. 2009 153(1):75-82.
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Sarabdjitsingh RA, Meijer OC, Schaaf MJ, de Kloet ER (2009) Subregion-specific differences in translocation patterns of mineralocorticoid and glucocorticoid receptors in rat hippocampus. Brain Res. 1249:43-53.
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Versluis F, Tomatsu I, Kehr S, Fregonese C, Stuart MCA, Ravoo BJ, Koning RI, Kros A (2009) Shape and release control of a vesicle through the pH sensitive secondary structure transition of a non-covalently bound oligopeptide. J. Am. Chem. Soc. 131:13186–13187.
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Oitzl MS, Champagne DL, van der Veen R, de Kloet ER (2009) Brain development under stress: hypotheses of glucocorticoid actions revisited. Neurosci. & Biobehav. Rev (Epub, ahead of print).
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Smit-Rigter LA, Champagne DL, van Hooft JA (2009) Lifelong impact of variations in maternal care on dendritic structure and function of cortical layer 2/3 pyramidal neurons in rat offspring. PLoS ONE 4:e5167.
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Vreugdenhil E, Verissimo C, Mariman R, Kamphuis JT, Barbosa JS, Champagne DL, Meijer OC, de Kloet ER, Fitzsimons C. (2009) Discovery of a Novel Role for MicroRNAs miR-18 and miR-124 in Reducing Glucocorticoid Receptor Activity and GR Protein Levels: Implications for the Regulation of Glucocorticoid Responsiveness. Endocrinology 150:2220-2228.
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Champagne DL, de Kloet ER, Joels M (2009) Fundamental aspects of the impact of glucocorticoids on the (immature) brain. Seminars in Fetal and Neonatal Medicine 14(3):136-42.
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de Jong IM, Colbert MW, Witte F, Richardson MK (2009) Polymorphism in developmental timing: intraspecific heterochrony in a Lake Victoria cichlid. Evol Dev. 11(6):625-35.
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de Jong IM, Witte F, Richardson MK (2009) Developmental stages until hatching of the Lake Victoria cichlid Haplochromis piceatus (Teleostei: Cichlidae).J Morphol. 270(5):519-35.
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Blackburn DG, Richardson MK (2009) Preface to the symposium "Trends in the Evolution of Amniote Embryos". J Exp Zool B Mol Dev Evol. 312(6):525.
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Chuong CM, Richardson MK (2009) Pattern formation today. Int J Dev Biol. 53(5-6):653-8.
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Chuong CM, Richardson MK (2009) Preface to pattern formation special issue. Int J Dev Biol. 53(5-6):651.
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Woltering JM, Vonk FJ, Müller H, Bardine N, Tuduce IL, de Bakker MA, Knöchel W, Sirbu IO, Durston AJ, Richardson MK (2009) Axial patterning in snakes and caecilians: evidence for an alternative interpretation of the Hox code. Dev Biol. 332(1):82-9.
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Richardson MK, Gobes SM, van Leeuwen AC, Polman JA, Pieau C, Sánchez-Villagra MR (2009) Heterochrony in limb evolution: developmental mechanisms and natural selection. J Exp Zool B Mol Dev Evol. 312(6):639-64.
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De Vrieze E, Metz JR, Von den Hoff JW, Flik G (2010) ALP, TRAcP and cathepsin K in elasmoid scales: a role in mineral metabolism? Journal of Applied Ichthyology 26:210-213.
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De Vrieze E, Sharif F, Metz JR, Flik G, Richardson MK. Matrix metalloproteinases in osteoclasts of ontogenetic and regenerating zebrafish scales. Bone [Epub ahead of print]
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Peng K, Cui C, Tomatsu I, Meijer AH, Spaink HP, Kros A (2010) Cyclodextrin/dextran based drug carriers for a controlled release of hydrophobic drugs in zebrafish embryos. Soft Matter 6:3778–3783.
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Peng K, Tomatsu I, Kros A (2010) Light controlled protein release from a supramolecular hydrogel. Chem. Commun. 46:4094 – 4096.
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Peng K, Tomatsu I, Korobko AV, Kros A (2010) Rapid in Situ Forming Cross-linked Dextran/β-cyclodextrin Hydrogels for the Delivery of Hydrophobic Drugs. Soft Matter 6:85-87.
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Schoonheim PJ, Chatzopoulou A, Schaaf MJ (2010) The zebrafish as an in vivo model system for glucocorticoid resistance. Steroids. 75(12):918-25.
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Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AMC, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD (2010) Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. PNAS 107:13614-19.
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Yuan H, De Bruijn J (2010) Heterotopic bone formation by nano-apatite containing poly(D,L-lactide) composites.EUROPEAN CELLS & MATERIALS19:252-261.
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Barbieri D, Renard AJS, de Bruijn JD, Yuan H (2010) Heterotopic bone formation by nano-apatite containing poly(D,LLactide) composites. European Cells & Materials 19:252-61.
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Claessens SE, Daskalakis NP, van der Veen R, Oitzl MS, de Kloet ER, Champagne DL (2010) Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences. Psychopharmacology (Berl) (epu ahead of print).
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Champagne DL, Hoefnagels C, de Kloet ER, Richardson MK (2010) Translating Rodent Behavioral Repertoire to Zebrafish (Danio rerio): Relevance for Stress Research. Behav Brain Res. 214:332-42.
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Qiu S, Champagne DL, Peters M, Weeber EJ, Levitt P, Pimenta AF (2010) Loss of limbic system-associated membrane protein leads to reduced hippocampal mineralocorticoid receptor expression, impaired synaptic plasticity and spatial memory deficit.Biol Psychiatry 68(2):197-204.
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Ali S, Champagne DL, van der Mil HA, Richardson MK. Critical assessment of the zebrafish embryo as a predictive model for the acute drug toxicity (In preparation for Toxicological Sciences).
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Richardson MK, Admiraal J, Wright GM (2010) Developmental anatomy of lampreys. Biol Rev Camb Philos Soc. 85(1):1-33.
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Siang AS, Doley R, Vonk FJ, RM Kini (2010) Transcriptomic Analysis of the Venom Gland of the Red-headed Krait (Bungarus flaviceps) Using Expressed Sequence Tags. BMC Molecular Biology 11, 24.
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Ali S, Champagne DL, Richardson MK. Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds. Behav Brain Res. In press
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Ali S, Champagne DL, Alia A, Richardson MK (2011) Large-Scale Analysis of Acute Ethanol Exposure in Zebrafish Development: a Critical Time Window and Resilience. PloS One. 6(5): e20037.doi:10.1371/journal.pone.0020037
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Ali S, Champagne DL, Spaink HP, Richardson MK. Zebrafish embryos and larvae: A new generation of disease models and drug screens. Birth Defects Res C Embryo today. 93:115-33
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Ali S, van Mil HGJ, Richardson MK (2011) Large-Scale Assessments of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing. PLoS One. 6(6): e21076. doi:0.1371/journal.pone.0021076.
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Arjona FJ, de Vrieze E, Visser TJ, Flik G, Klaren PHM (2011) Identification and functional characterization of zebrafish solute carrier Slc16a2 (Mct8) as a thyroid hormone membrane transporter. Endocrinology 152:5065-73.
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Daskalakis NP, Claessens SE, Laboyrie JJ, Enthoven L, Oitzl MS, Champagne DL, et al. The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion. Horm Behav.
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Daskalakis, NP, Oitzl MS, Schächinger H, Champagne DL, de Kloet, ER. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity.. Article in press in Physiology & Behavior (ref: PHB-D-11-00647R1)
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Gorissen M, de Vrieze E, Flik G, Huising MO (2011) STAT genes display differential evolutionary rates that correlate with their roles in the endocrine and immune system. J Endocrinol. 209:175-84.
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Sharif F, Porta F, Meijer AH, Kros A, Richardson MK. Silica nanoparticles as a compound delivery system in zebrafish embyos. International Journal of Nanomedicine, in press.
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Porta F, Lamers GEM, Zink JI, Kros A (2011) Peptide modified mesoporous silica nanocontainers. Phys. Chem. Chem. Phys. 13:9982-9985.
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Schnorr SJ, Steenbergen PJ, Richardson MK, Champagne DL (2011) Measuring thigmotaxis in Iarval zebrafish. Behav Brain Res. 228(12):367-74.
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Steenbergen PJ, Richardson MK, Champagne, DL (2011) Patterns of avoidance behaviours in the light/dark preference test in young juvenile zebrafish: a pharmacological study. Behav Brain Res. 222:15-25
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Steenbegen PJ, Richardson MK, Champagne DL. The use of the zebrafish model in stress research. Prog Neuropsychopharmacol Biol Psychiatryl. 35:1432-51.
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Vonk FJ, Jackson K, Doley R et al. (2011) Snake venom: From fieldwork to the clinic. BIOESSAYS 33(4):269-179.
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de Vrieze E, Sharif F, Metz JR, Flik G, Richardson MK (2011) Matrix metalloproteinases in osteoclasts of ontogenetic and regenerating zebrafish scales. Bone 48:704-12.
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Wielhouwer EM, Ali S, Al-Afandi A, Richardson MK et al (2011) Zebrafish embryos development in a microfluidic flow-through system. Lab on a chip 11(10):1815-1824.
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Radboud University: Two papers for the Journal of Applied Ichtyology (Interdisciplinary Approaches in Fish Skeletal Biology, special issue) are pending.
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Work Package 4:
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Hoekema A (2007) Galapagos and GSK: An innovative alliance in osteoarthritis. Global Outsourcing Review 9: 26-28.
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Hoekema A (2007) Sharing risks and rewards: basis for a turnkey pharma-biotech alliance in osteoarthritis. Drug Discovery World 8: 53-58.
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Joubert O, Nehmé R, Fleury D, De Rivoyre M, Bidet M, Polidori A, Ruat M, Pucci B, Mollat P, Mus-Veteau I (2009) Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast. Biochim Biophys Acta. 1788(9):1813-21.
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Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC (2009) Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 9:26.
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Hourdé C, Jagerschmidt C, Clément-Lacroix P, Vignaud A, Ammann P, Butler-Browne GS, Ferry A (2009) Androgen replacement therapy improves function in male rat muscles independently of hypertrophy and activation of the Akt/mTOR pathway. Acta Physiol (Oxf). 195(4):471-82.
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Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann M, Deprez P, Clément-Lacroix P, Bettler B, Bräuner-Osborne J(2009) No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Mol. Endocrinol. 42(3):215-23
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Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delecourte A, Fischer DF, Pollet D, De Strooper B, and Merchiers P (2009) The orphan G protein coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science 323(5916):946-951.
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Kollias G, Papadaki P, Apparaille F, Vervoordeldonk MJ, Holmdahl R, Gay S et al (2011) Animal models for arthritis: innovative tools for prevention and treatments Eular study group on animal models-Guidance document. ANNALS OF THE RHEUMATIC DISEASES 70(8): 1357-1362
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